Possible dangers of a “nutritional supplement” lithium orotate

TO THE EDITOR: A resident at our university clinic recently evaluated a patient who reported using lithium orotate, 240 mg/d, for self-diagnosed bipolar disorder (BD) (diagnosis was not confirmed, the patient did not show signs of toxicity). Lithium orotate is a salt of orotic acid and lithium. It is widely available over the Internet (eg, Amazon.com) and marketed as a dietary supplement for conditions such as BD, alcoholism, and aggression, although it is not FDAapproved for any indication. Lithium orotate is available in some drug stores and health food stores under various brand names (eg, “Doctor’s Best Lithium Orotate”)…

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