Validation of a diagnostic screening blood test for bipolar disorderDouglas B. Woodruff, MD
Clinical Psychiatrist, Baltimore, MD, USARif S. El-Mallakh, MD
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USAAlagu P. Thiruvengadam, PhD
PsychNostics, Baltimore, MD, USA
BACKGROUND: Bipolar disorder is difficult to diagnose, and probably is both overdiagnosed and underdiagnosed. Misdiagnosis has deleterious consequences for the prognosis of the disorder. In a previous study (n=134), measurement of blood cellular membrane potential (expressed as membrane potential ratio [MPR™]) diagnosed bipolar illness with a sensitivity of .78 and a specificity of .88. The current study was performed as a validation of the initial study.
METHODS: We recruited consecutive outpatients with DSM-IV-diagnosed bipolar I disorder (BD I) and those without bipolar illness (n=153) and measured their MPR™.
RESULTS: BD I patients were relatively hyperpolarized, with an MPR™ of .601 (± standard deviation .0179), compared with non-bipolar patients (MPR™ .675±.0174). The sensitivity and specificity for BD I are .93 and .90, respectively.
CONCLUSIONS: Before clinical application, future studies must utilize consensus diagnosis as the “gold standard” diagnosis and examine the effect of mood-stabilizing drugs on MPR™.
KEYWORDS: diagnosis, screening, blood test, bipolar disorder, validation
ANNALS OF CLINICAL PSYCHIATRY 2012;24(2):135-139CORRESPONDENCE: Rif S. El-Mallakh, MD, Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, MedCenter One, 501 E. Broadway, Suite 340, Louisville, KY 40202 USA E-MAIL: email@example.comAnnals of Clinical Psychiatry ©2012 Quadrant HealthCom Inc.