May 2012  << Back  

Validation of a diagnostic screening blood test for bipolar disorder

Douglas B. Woodruff, MD

Clinical Psychiatrist, Baltimore, MD, USA

Rif S. El-Mallakh, MD

Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA

Alagu P. Thiruvengadam, PhD

PsychNostics, Baltimore, MD, USA

BACKGROUND: Bipolar disorder is difficult to diagnose, and probably is both overdiagnosed and underdiagnosed. Misdiagnosis has deleterious consequences for the prognosis of the disorder. In a previous study (n=134), measurement of blood cellular membrane potential (expressed as membrane potential ratio [MPR™]) diagnosed bipolar illness with a sensitivity of .78 and a specificity of .88. The current study was performed as a validation of the initial study.

METHODS: We recruited consecutive outpatients with DSM-IV-diagnosed bipolar I disorder (BD I) and those without bipolar illness (n=153) and measured their MPR™.

RESULTS: BD I patients were relatively hyperpolarized, with an MPR™ of .601 (± standard deviation .0179), compared with non-bipolar patients (MPR™ .675±.0174). The sensitivity and specificity for BD I are .93 and .90, respectively.

CONCLUSIONS: Before clinical application, future studies must utilize consensus diagnosis as the “gold standard” diagnosis and examine the effect of mood-stabilizing drugs on MPR™.

KEYWORDS: diagnosis, screening, blood test, bipolar disorder, validation

ANNALS OF CLINICAL PSYCHIATRY 2012;24(2):135-139

CORRESPONDENCE: Rif S. El-Mallakh, MD, Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, MedCenter One, 501 E. Broadway, Suite 340, Louisville, KY 40202 USA E-MAIL: rselma01@louisville.edu
Annals of Clinical Psychiatry ©2012 Quadrant HealthCom Inc.

 
Read full article