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The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid anxiety disorders

Ayal Schaffer, MD, FRCPC

Mood and Anxiety Disorders Program, Sunnybrook Health Sciences Centre, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

Diane McIntosh, MD, FRCPC

Copeman Healthcare Centre, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada

Benjamin I. Goldstein, MD, PhD, FRCPC

Youth Bipolar Disorders Program, Sunnybrook Health Sciences Centre, Department of Psychiatry, University of Toronto , Toronto, Ontario, Canada

Neil A. Rector, PhD, CPsych

Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

Roger S. McIntyre, MD, FRCPC

Mood Disorders Psychopharmacology Unit, University Health Network, Departments of Psychiatry and Pharmacology, University of Toronto , Toronto, Ontario, Canada

Serge Beaulieu, MD, PhD, FRCPC

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Québec, Canada

Richard Swinson, MD, FRCPC

Anxiety Treatment and Research Centre, St. Joseph’s Healthcare, Department of Psychiatry and Behavioral Neurosciences, McMaster University , Hamilton, Ontario, Canada

Lakshmi N. Yatham, MBBS, FRCPC, MRCPsych (UK)

Research and International Affairs, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada

BACKGROUND: Comorbid mood and anxiety disorders are commonly seen in clinical practice. The goal of this article is to review the available literature on the epidemiologic, etiologic, clinical, and management aspects of this comorbidity and formulate a set of evidence- and consensus-based recommendations. This article is part of a set of Canadian Network for Mood and Anxiety Treatments (CANMAT) Comorbidity Task Force papers.

METHODS: We conducted a PubMed search of all English-language articles published between January 1966 and November 2010. The search terms were bipolar disorder and major depressive disorder, cross-referenced with anxiety disorders/symptoms, panic disorder, agoraphobia, generalized anxiety disorder, social phobia, obsessive-compulsive disorder, and posttraumatic stress disorder. Levels of evidence for specific interventions were assigned based on a priori determined criteria, and recommendations were developed by integrating the level of evidence and clinical opinion of the authors.

RESULTS: Comorbid anxiety symptoms and disorders have a significant impact on the clinical presentation and treatment approach for patients with mood disorders. A set of recommendations are provided for the management of bipolar disorder (BD) with comorbid anxiety and major depressive disorder (MDD) with comorbid anxiety with a focus on comorbid posttraumatic stress disorder, use of cognitive-behavioral therapy across mood and anxiety disorders, and youth with mood and anxiety disorders.

CONCLUSIONS: Careful attention should be given to correctly identifying anxiety comorbidities in patients with BD or MDD. Consideration of evidence- or consensus-based treatment recommendations for the management of both mood and anxiety symptoms is warranted.

KEYWORDS: bipolar disorder, major depressive disorder, anxiety, panic disorder, generalized anxiety disorder, obsessive-compulsive disorder, social phobia, posttraumatic stress disorder

ANNALS OF CLINICAL PSYCHIATRY 2012;24(1):6-22

CORRESPONDENCE: Ayal Schaffer, MD, FRCPC, Mood and Anxiety Disorders Program, Sunnybrook Health Sciences Centre, Department of Psychiatry, University of Toronto, 2075 Bayview Avenue, Room FG 29, Toronto, ON M4N 3M5 Canada, E-MAIL: ayal.schaffer@sunnybrook.ca
Annals of Clinical Psychiatry ©2012 Quadrant HealthCom Inc.

 
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